I don't think this game will cater to "carebears" and I think if you're going into this game expecting to just spend all your time on Arboreus safely PvEing this game probably won't be for you.
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Full loot shows that the devs intend for this game to be fairly hardcore. They want risk to be involved. A self-contained extremely safe Arboreus goes against the idea of risk.
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They described Arboreus as PvE-centric, not PvE exclusive. Just like Tartaros will be PvP-centric but will most likely also have plenty of PvE. I strongly suspect the safe areas of Arboreus will mostly be the big hubs, and venturing away from those hubs will always always carry risk; decreased risk compared to other planets, but risk nontheless. I very much doubt spending all your time in safe zones will be rewarding or fun.
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The knowledge system is heavily exploration based. You will have to leave your safe zones to develop your talents and abilities. What is a carebear going to do when they have to travel to Tartaros to learn an ability they want or to upgrade one of their abilities?
I feel for those who are looking to live their digital lives as peaceful farmers permanently safe from all those evil gankers, but from what we know about the game so far, I don't think it will really support that. The closest you might get is joining a guild and living on their settlement as peacefully as you can under their protection, but there will never be guaranteed safety.