A few Talents I've defined for my own world:
Cauterization - Fire-based healing tree. Almost all heals in my world are over time, but Cauterization allows faster / instant healing at the cost of temporary debuffs (e.g. stop bleeding by burning the #(!@ out of your wounds). Cauterization can also counter regenning enemies such as trolls.
Larceny - Not only does this let you pick locks and pockets, but it also lets you impersonate NPCs and (to an extent) player characters. You can even make knockoff items to try to pass off to merchants. Oh, and you can "plagiarize" other people's skills too. (Not sure how useful that is in a game where you can get every skill already.)
[various forms of] Lore - Item lore, spell lore, rune lore, etc. help you to identify well-crafted or valuable items and, more importantly, cursed items from all those tombs you keep looting. There's also a perk to selling these things to shopkeepers.
Summoning - In addition to the usual get-you-a-pet-to-hit-things, "Audacity" allows you to speak with gods and "Profane Ritual" allows you to attempt to summon demons and God-Beasts as guild bosses. Oh, and you can summon other players, too.
Tracking - All actions performed such as walking leave traces such as footsteps or scent trails. By taking Tracking, you not only become better at spotting & following these traces, but also better at not leaving them yourself (e.g. cover yourself in mud to reduce scent emissions until you next enter water.) Basically, Stealth determines if someone in the same room can see you, Tracking determines if someone half a country away can hunt you down.
Riding - Makes you better at mount shenanigans - faster, less likely to fall off, etc. With most Weapon Talents this forms a Cross Talent that lets you fight while mounted and even be "stronger" when mounted than on foot; in particular, Riding + Spearplay = Jousting.
@Gothix
Haha
I always remember that blood epidemic in WoW. Maybe if they had epidemiologists it wouldn't be such a disaster! xD
They did! It was the first case of real-world epidemiologists studying a video game disease and was in the headlines for quite some time until Corrupted Blood was patched.
Ingame, people formed quarantines and there were bio-terrorists trying to spread the disease as much as possible, just like in real life.
I'm 100% sure Blizzard waited to patch it until they stopped getting free attention for it.